Article
Allele variants in functional MicroRNA target sites of the neurotrophin-3 receptor gene (NTRK3) as susceptibility factors for anxiety disorders.
Human mutation - 1 Jul 2009
Muiños-Gimeno Margarita, Guidi Monica, Kagerbauer Birgit, Martín-Santos Rocío, Navinés Ricard, Alonso Pino, Menchón José M, Gratacòs Mònica, Estivill Xavier, Espinosa-Parrilla Yolanda
Abstract excerpt
Genetic and functional data indicate that variation in the expression of the neurotrophin-3 receptor gene (NTRK3) may have an impact on neuronal plasticity, suggesting a role for NTRK3 in the pathophysiology of anxiety disorders. MicroRNA (miRNA) posttranscriptional gene regulators act by base-pairing to specific sequence sites, usually at the 3'UTR of the target mRNA. Variants at these sites might result in gene...
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