Article
Proposed endophenotypes of dysthymia: evolutionary, clinical and pharmacogenomic considerations.
Molecular psychiatry - 1 Jul 2001
Niculescu A B, Akiskal H S
Abstract excerpt
Dysthymia is highly prevalent--though underdiagnosed--occurring in at least 3% of the population. We conceptualize it as the clinical extension of adaptive traits that have developed during evolution to cope with stress and failure. A classification of dysthymias into anxious and anergic subtypes--and their putative association to bipolarity--is proposed. We further posit neurochemical and neurophysiological...
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