Article
No evidence for association between a non-synonymous polymorphism in the gene encoding human metabotropic glutamate receptor 7 and schizophrenia.
Psychiatric genetics - 1 Jun 2000
Bray N J, Williams N M, Bowen T, Cardno A G, Gray M, Jones L A, Murphy K C, Sanders R D, Spurlock G, Odonovan M C, Owen M J
Abstract excerpt
The cDNA sequence of the gene encoding human metabotropic glutamate receptor type 7 (mGluR7) contains the single nucleotide polymorphism 1536A > T [GenBank sequence X94552 (Makoff et al., 1996)]. This sequence variation is predicted to result in an amino acid change (F433Y) in the gene product and thus has the potential to affect receptor function. Since disturbances in glutamate function have been implicated in...
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