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Article

Mutational analysis of substrate inhibition in tyrosine hydroxylase.

Journal of neurochemistry - 1 Nov 1998

Quinsey N S, Luong A Q, Dickson P W

Abstract excerpt

Substrate inhibition in tyrosine hydroxylase (TH) was analyzed by deletion mutagenesis. The deletion mutant TH 156/456 was the smallest section of TH to retain substrate inhibition. The TH 156/456 was monomeric, and so multimer formation does not play a role in substrate inhibition in TH. Further deletion at the N terminus to residue 169 produced a TH molecule with no substrate inhibition but high activity. A...

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Identifiers

PMID: 9798939
DOI: 10.1046/j.1471-4159.1998.71052132.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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