Mutational analysis of substrate inhibition in tyrosine hydroxylase.

doi:10.1046/j.1471-4159.1998.71052132.x

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Article

Mutational analysis of substrate inhibition in tyrosine hydroxylase.

Journal of neurochemistry - 1 Nov 1998

Quinsey N S, Luong A Q, Dickson P W

Abstract excerpt

Substrate inhibition in tyrosine hydroxylase (TH) was analyzed by deletion mutagenesis. The deletion mutant TH 156/456 was the smallest section of TH to retain substrate inhibition. The TH 156/456 was monomeric, and so multimer formation does not play a role in substrate inhibition in TH. Further...

Topics

Amino Acid Sequence
Chemical Phenomena
Chemistry, Physical
DNA Mutational Analysis
Gene Deletion
Gene Library
Mutagenesis, Site-Directed
Mutation
Phenotype
Substrate Specificity
Tyrosine 3-Monooxygenase

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