Article
Coordinate regulation of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 expression in human vascular smooth muscle cells.
Connective tissue research - 1 Jan 2000
Kato S, Yasukawa H, Fujii T, Yamaguchi M, Miyagi N, Okamoto K, Wada Y, Miyamoto T, Morimatsu M, Fox J C
Abstract excerpt
The expression of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) by human vascular smooth muscle cells (SMC) was monitored as a function of the phenotypic modulation in vitro. Cell phenotype was manipulated by varying serum concentration and cell density. Synthetic phenotype was characterized by a minimum expression of the contractile proteins and a maximal proliferation rate. Contractile phenotype...
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