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Article

Two proteins with the same structure respond very differently to mutation: the role of plasticity in protein stability.

Journal of molecular biology - 22 Sept 2000

Cota E, Hamill S J, Fowler S B, Clarke J

Abstract excerpt

As part of a systematic study of the folding of protein structural families we compare the effect of mutation in two closely related fibronectin type III (fnIII) domains, the tenth fnIII domain of human fibronectin (FNfn10) and the third fnIII domain of human tenascin (TNfn3). This comparison of the two related proteins allows us to distinguish any anomalous response to mutation. Although they have very similar...

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Identifiers

PMID: 10986129
DOI: 10.1006/jmbi.2000.4053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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