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Article

Conservation of folding and stability within a protein family: the tyrosine corner as an evolutionary cul-de-sac.

Journal of molecular biology - 21 Jan 2000

Hamill S J, Cota E, Chothia C, Clarke J

Abstract excerpt

What are the selective pressures on protein sequences during evolution? Amino acid residues may be highly conserved for functional or structural (stability) reasons. Theoretical studies have proposed that residues involved in the folding nucleus may also be highly conserved. To test this we are using an experimental "fold approach" to the study of protein folding. This compares the folding and stability of a...

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Source

Identifiers

PMID: 10623553
DOI: 10.1006/jmbi.1999.3360

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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