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Article

Mechanical unfolding of TNfn3: the unfolding pathway of a fnIII domain probed by protein engineering, AFM and MD simulation.

Journal of molecular biology - 22 Jul 2005

Ng Sean P, Rounsevell Ross W S, Steward Annette, Geierhaas Christian D, Williams Philip M, Paci Emanuele, Clarke Jane

Abstract excerpt

Protein engineering Phi-value analysis combined with single molecule atomic force microscopy (AFM) was used to probe the molecular basis for the mechanical stability of TNfn3, the third fibronectin type III domain from human tenascin. This approach has been adopted previously to solve the forced unfolding pathway of a titin immunoglobulin domain, TI I27. TNfn3 and TI I27 are members of different protein...

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Identifiers

PMID: 15964016
DOI: 10.1016/j.jmb.2005.04.070

Genes

AFM

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