Article
Analyses of Mutation Displacements from Homology Models.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2023
Carpentier Mathilde, Chomilier Jacques
Abstract excerpt
Evaluation of the structural perturbations introduced by a single amino acid mutation is the main issue for protein structural biology. We propose here to present some recent advances in methods, allowing the splitting of distortion between the actual substitution effect and the contribution of the local flexibility of the position where the mutation occurs. Its main drawback is the need of many structures with a...
Topics
- Humans
- Mutation
- Proteins
- Software
- Models, Molecular
- Algorithms
- Protein Conformation