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Article

PEGylation Increases the Strength of a Nearby NH-π Hydrogen Bond in the WW Domain.

Biochemistry - 6 Jul 2021

Draper Steven R E, Jones Zachary B, Earl Seth O, Dalley Nicholas A, Ashton Dallin S, Carter Anthony J, Conover Benjamin M, Price Joshua L

Abstract excerpt

Here we show that an NH-π interaction between a highly conserved Asn and a nearby Trp stabilizes the WW domain of the human protein Pin1. The strength of this NH-π interaction depends on the structure of the arene, with NH-π interactions involving Trp or naphthylalanine being substantially more stabilizing than those involving Tyr or Phe. Calculations suggest arene size and polarizability are key structural...

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Identifiers

PMID: 34137579
DOI: 10.1021/acs.biochem.1c00132
PMCID: PMC8406554

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