Article
Use of anion-aromatic interactions to position the general base in the ketosteroid isomerase active site.
Proceedings of the National Academy of Sciences of the United States of America - 9 Jul 2013
Schwans Jason P, Sunden Fanny, Lassila Jonathan K, Gonzalez Ana, Tsai Yingssu, Herschlag Daniel
Abstract excerpt
Although the cation-pi pair, formed between a side chain or substrate cation and the negative electrostatic potential of a pi system on the face of an aromatic ring, has been widely discussed and has been shown to be important in protein structure and protein-ligand interactions, there has been little discussion of the potential structural and functional importance in proteins of the related anion-aromatic pair...
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