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Article

GMMA Can Stabilize Proteins Across Different Functional Constraints.

Journal of molecular biology - 1 Jun 2024

Daffern Nicolas, Johansson Kristoffer E, Baumer Zachary T, Robertson Nicholas R, Woojuh Janty, Bedewitz Matthew A, Davis Zoë, Wheeldon Ian, Cutler Sean R, Lindorff-Larsen Kresten, Whitehead Timothy A

Abstract excerpt

Stabilizing proteins without otherwise hampering their function is a central task in protein engineering and design. PYR1 is a plant hormone receptor that has been engineered to bind diverse small molecule ligands. We sought a set of generalized mutations that would provide stability without affecting functionality for PYR1 variants with diverse ligand-binding capabilities. To do this we used a global...

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Identifiers

PMID: 38663544
DOI: 10.1016/j.jmb.2024.168586

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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