Article
Mutations in a tRNA import signal define distinct receptors at the two membranes of Leishmania mitochondria.
Molecular and cellular biology - 1 Oct 2000
Bhattacharyya S N, Mukherjee S, Adhya S
Abstract excerpt
Nucleus-encoded tRNAs are selectively imported into the mitochondrion of Leishmania, a kinetoplastid protozoan. An oligoribonucleotide constituting the D stem-loop import signal of tRNA(Tyr)(GUA) was efficiently transported into the mitochondrial matrix in organello as well as in vivo. Transfer through the inner membrane could be uncoupled from that through the outer membrane and was resistant to antibody against...
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