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Article

Structural requirements of tRNALys for its import into yeast mitochondria.

Proceedings of the National Academy of Sciences of the United States of America - 17 Mar 1998

Entelis N S, Kieffer S, Kolesnikova O A, Martin R P, Tarassov I A

Abstract excerpt

In the yeast Saccharomyces cerevisiae, one of the two cytoplasmic lysine tRNAs, tRNACUULys, is partially associated with the mitochondrial matrix. Mitochondrial import of this tRNA requires binding to the precursor of the mitochondrial lysyl-tRNA synthetase, pre-MSK, and aminoacylation by the cytoplasmic lysyl-tRNA synthetase, KRS, appears to be a prerequisite for this binding. The second lysine isoacceptor...

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Identifiers

PMID: 9501177
DOI: 10.1073/pnas.95.6.2838
PMCID: PMC19656

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