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Article

Functional delivery of a cytosolic tRNA into mutant mitochondria of human cells.

Science (New York, N.Y.) - 20 Oct 2006

Mahata Bidesh, Mukherjee Saikat, Mishra Sumita, Bandyopadhyay Arun, Adhya Samit

Abstract excerpt

Many maternally inherited and incurable neuromyopathies are caused by mutations in mitochondrial (mt) transfer RNA (tRNA) genes. Kinetoplastid protozoa, including Leishmania, have evolved specialized systems for importing nucleus-encoded tRNAs into mitochondria. We found that the Leishmania RNA import complex (RIC) could enter human cells by a caveolin-1-dependent pathway, where it induced import of endogenous...

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PMID: 17053148
DOI: 10.1126/science.1129754

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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