Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A sequence motif within trypanosome precursor tRNAs influences abundance and mitochondrial localization.

Molecular and cellular biology - 1 Dec 2003

Sherrer R Lynn, Yermovsky-Kammerer Audra E, Hajduk Stephen L

Abstract excerpt

Trypanosoma brucei lacks mitochondrial genes encoding tRNAs and must import nuclearly encoded tRNAs from the cytosol. The mechanism and specificity of this process remain unclear. We have identified a unique sequence motif, YGG(C/A)RRC, upstream of the genes encoding mitochondrially localized tRNAs in T. brucei. Both in vitro import studies and in vivo transfection studies indicate that deletion of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Transport, Active
Share to Conserved Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytosol

Share to RNA Precursors

Share to RNA Processing, Post-Transcriptional

Share to RNA, Protozoan

Share to RNA, Transfer, Leu

Share to Trypanosoma brucei brucei

Source

Open in PubMed Open full text

Identifiers

PMID: 14645518
DOI: 10.1128/MCB.23.24.9061-9072.2003
PMCID: PMC309662

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A sequence motif within trypanosome precursor tRNAs influences abundance and mitochondrial localization.PMID 14645518Read ↗

Key RNA-binding domains in the La protein establish tRNA modification levels in Trypanosoma bruceiSemantic proximity Read ↗

The T-stem determines the cytosolic or mitochondrial localization of trypanosomal tRNAsMet.Semantic proximity Read ↗

tRNAs are imported into mitochondria of Trypanosoma brucei independently of their genomic context and genetic origin.Semantic proximity Read ↗

Alternative mRNA editing in trypanosomes is extensive and may contribute to mitochondrial protein diversity.Semantic proximity Read ↗

Dual targeting of isoleucyl-tRNA synthetase in Trypanosoma brucei is mediated through alternative trans-splicingSemantic proximity Read ↗

RNA editing in trypanosomatid mitochondria.Semantic proximity Read ↗

Mitochondrial translation is essential in bloodstream forms of Trypanosoma bruceiSemantic proximity Read ↗

tRNA mitochondrial import in yeast: Mapping of the import determinants in the carrier protein, the precursor of mitochondrial lysyl-tRNA synthetase.Semantic proximity Read ↗

The nuclear tRNA aminoacylation-dependent pathway may be the principal route used to export tRNA from the nucleus in Saccharomyces cerevisiae.Semantic proximity Read ↗

Targeting mitochondrial and cytosolic substrates of TRIT1 isopentenyltransferase: Specificity determinants and tRNA-i6A37 profiles.Semantic proximity Read ↗

Genomic organization of <i>Trypanosoma cruzi</i> tRNA genesSemantic proximity Read ↗

Sequence dependence of tRNA(Gly) import into tobacco mitochondria.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.