Effects of omeprazole on intragastric pH and plasma gastrin are dependent on the CYP2C19 polymorphism.

doi:10.1053/gast.2000.16515

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Article

Effects of omeprazole on intragastric pH and plasma gastrin are dependent on the CYP2C19 polymorphism.

Gastroenterology - 1 Sept 2000

Sagar M, Tybring G, Dahl M L, Bertilsson L, Seensalu R

Abstract excerpt

BACKGROUND & AIMS: Omeprazole is metabolized by cytochrome P450 (CYP2C19). The activity of this enzyme is polymorphic, with incidences of poor metabolizers (PMs), heterozygous extensive metabolizers (EMs), and homozygous EMs in white populations of 3%, 30%, and 67%, respectively. The importance of the CYP2C19 polymorphism for the effects of omeprazole on intragastric pH and plasma gastrin concentrations has been...

Topics

Aged
Alleles
Anti-Ulcer Agents
Aryl Hydrocarbon Hydroxylases
Cytochrome P-450 CYP2C19
Cytochrome P-450 Enzyme System
Female
Gastric Acid
Gastrins
Genotype
Helicobacter pylori
Heterozygote
Homozygote
Humans
Hydrogen-Ion Concentration

Source

Open in PubMed

Identifiers

PMID: 10982760
DOI: 10.1053/gast.2000.16515

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Male

Middle Aged

Mixed Function Oxygenases