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Article

Effects of omeprazole on intragastric pH and plasma gastrin are dependent on the CYP2C19 polymorphism.

Gastroenterology - 1 Sept 2000

Sagar M, Tybring G, Dahl M L, Bertilsson L, Seensalu R

Abstract excerpt

BACKGROUND & AIMS: Omeprazole is metabolized by cytochrome P450 (CYP2C19). The activity of this enzyme is polymorphic, with incidences of poor metabolizers (PMs), heterozygous extensive metabolizers (EMs), and homozygous EMs in white populations of 3%, 30%, and 67%, respectively. The importance of the CYP2C19 polymorphism for the effects of omeprazole on intragastric pH and plasma gastrin concentrations has been...

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Source

Identifiers

PMID: 10982760
DOI: 10.1053/gast.2000.16515

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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