Article
CYP2C19 genotype status and effect of omeprazole on intragastric pH in humans.
Clinical pharmacology and therapeutics - 1 May 1999
Furuta T, Ohashi K, Kosuge K, Zhao X J, Takashima M, Kimura M, Nishimoto M, Hanai H, Kaneko E, Ishizaki T
Abstract excerpt
OBJECTIVE: Omeprazole is metabolized by genetically determined S-mephenytoin 4'-hydroxylase (CYP2C19) in the liver. This study aimed to determine whether the effect of omeprazole on intragastric pH depends on CYP2C19 genotype status. METHODS: CYP2C19 genotype status for 2 mutations associated with the poor metabolizer phenotype was determined by a polymerase chain reaction-restriction fragment length polymorphism...
Topics
- Adult
- Anti-Ulcer Agents
- Area Under Curve
- Aryl Hydrocarbon Hydroxylases
- Asian People
- Cytochrome P-450 CYP2C19
- Cytochrome P-450 Enzyme Inhibitors
- Cytochrome P-450 Enzyme System
- Enzyme Inhibitors
- Female
- Gastric Mucosa
- Gastrins
- Genotype