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Article

CYP2C19 genotype status and effect of omeprazole on intragastric pH in humans.

Clinical pharmacology and therapeutics - 1 May 1999

Furuta T, Ohashi K, Kosuge K, Zhao X J, Takashima M, Kimura M, Nishimoto M, Hanai H, Kaneko E, Ishizaki T

Abstract excerpt

OBJECTIVE: Omeprazole is metabolized by genetically determined S-mephenytoin 4'-hydroxylase (CYP2C19) in the liver. This study aimed to determine whether the effect of omeprazole on intragastric pH depends on CYP2C19 genotype status. METHODS: CYP2C19 genotype status for 2 mutations associated with the poor metabolizer phenotype was determined by a polymerase chain reaction-restriction fragment length polymorphism...

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Identifiers

PMID: 10340921
DOI: 10.1016/S0009-9236(99)70075-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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