The Trp64Arg polymorphism of the beta3-adrenergic receptor gene is associated with hypertension in men with type 2 diabetes mellitus.

doi:10.1016/s0895-7061(00)00290-9

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Article

The Trp64Arg polymorphism of the beta3-adrenergic receptor gene is associated with hypertension in men with type 2 diabetes mellitus.

American journal of hypertension - 1 Sept 2000

Ringel J, Kreutz R, Distler A, Sharma A M

Abstract excerpt

A missense mutation of the beta3-adrenergic receptor gene (ADRB3) resulting in a tryptophan/arginine exchange at position 64 (Trp64Arg polymorphism) has recently been associated with greater capacity to gain weight, a low resting metabolic rate, higher blood pressure, and an early onset of type 2 diabetes. These findings prompted us to examine the relationship between this mutation, blood pressure, and vascular...

Topics

Aged
Alleles
Amino Acid Substitution
Blood Pressure
Diabetes Mellitus, Type 2
Diabetic Angiopathies
Female
Humans
Hypertension
Male
Middle Aged
Polymorphism, Genetic
Receptors, Adrenergic, beta

Source

Open in PubMed

Identifiers

PMID: 10981554
DOI: 10.1016/s0895-7061(00)00290-9

Genes

ADRB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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