Article
Relationships among the β3-adrenargic receptor gene Trp64Arg polymorphism, hypertension, and insulin resistance in a Japanese population.
PloS one - 1 Jan 2021
Yamada Youhei, Nakamura Haruki, Tsujiguchi Hiromasa, Hara Akinori, Miyagi Sakae, Kannon Takayuki, Sato Takehiro, Hosomichi Kazuyoshi, Nguyen Thao Thi Thu, Kambayashi Yasuhiro, Shimizu Yukari, Pham Kim Oanh, Suzuki Keita, Suzuki Fumihiko, Kasahara Tomoko, Tsuboi Hirohito, Tajima Atsushi, Nakamura Hiroyuki
Abstract excerpt
A polymorphism in the ADRB3 gene (Trp64Arg) has been associated with obesity, insulin resistance, and hypertension. This cross-sectional study investigated the relationships among this polymorphism, hypertension, and insulin resistance values (HOMA-IR) in 719 Japanese subjects aged 40 years and older. The genotype frequencies of Trp64Trp (homozygous, wild), Trp64Arg (heterozygous, variant), and Arg64Arg...
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