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Article

Mutations and copy number increase of HRAS in Spitz nevi with distinctive histopathological features.

The American journal of pathology - 1 Sept 2000

Bastian B C, LeBoit P E, Pinkel D

Abstract excerpt

Spitz nevus is a benign melanocytic neoplasm that can be difficult or impossible to histologically distinguish from melanoma. We have recently described copy number increases of chromosome 11p in a subset of Spitz nevi. To study the molecular and histological features of this group, we studied 102 Spitz nevi for 11p copy number increases using fluorescence in situ hybridization (FISH) on tissue arrays. Copy...

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Share to Chromosomes, Human, Pair 11
Share to DNA, Neoplasm
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genes, ras

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Share to In Situ Hybridization, Fluorescence

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Source

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Identifiers

PMID: 10980135
DOI: 10.1016/S0002-9440(10)64609-3
PMCID: PMC1885704

Genes

HRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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