Article
HRAS-mutated Spitz tumors: A subtype of Spitz tumors with distinct features.
The American journal of surgical pathology - 1 Oct 2010
van Engen-van Grunsven A C H, van Dijk Marcory C R F, Ruiter Dirk J, Klaasen Annelies, Mooi Wolter J, Blokx Willeke A M
Abstract excerpt
It is often very difficult to confidently distinguish benign and malignant Spitz lesions, and a diagnosis of Spitz tumor of unknown malignant potential (STUMP) is rendered. To address this problem, we performed molecular genetic analysis in a large group of Spitz tumors (93 Spitz nevi and 77 STUMPs) and identified a subgroup of 24 lesions harboring a HRAS mutation. This subgroup lay predominantly in the dermis,...
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