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Article

Genomic Fusions in Pigmented Spindle Cell Nevus of Reed.

The American journal of surgical pathology - 1 Aug 2018

VandenBoom Timothy, Quan Victor L, Zhang Bin, Garfield Erin M, Kong Betty Y, Isales Maria C, Panah Elnaz, Igartua Catherine, Taxter Timothy, Beaubier Nike, White Kevin, Gerami Pedram

Abstract excerpt

Recent molecular studies of spitzoid neoplasms have identified mutually exclusive kinase fusions involving ROS1, ALK, RET, BRAF, NTRK1, MET, and NTRK3 as early initiating genomic events. Pigmented spindle cell nevus (PSCN) of Reed is a morphologic variant of Spitz and may be very diagnostically challenging, having histologic features concerning for melanoma. Their occurrence in younger patients, lack of...

Topics

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Adolescent
Biomarkers, Tumor
Child
Child, Preschool
Gene Fusion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

High-Throughput Nucleotide Sequencing

In Situ Hybridization, Fluorescence

Source

Identifiers

PMID: 29794873
DOI: 10.1097/PAS.0000000000001074

Genes

NTRK3
ETV6
RET
ROS1
ALK
BRAF
MERTK
MET
NTRK1
PITX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Related research

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Genomic Fusions in Pigmented Spindle Cell Nevus of Reed.PMID 29794873Read ↗

Retrospective Cohort: Genomic Differences Between Pigmented Spindle Cell Nevi of Reed and Reed-Like Melanomas.Semantic proximity Read ↗

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Kinase Fusions in Spitz Melanocytic Tumors: The Past, the Present, and the FutureSemantic proximity Read ↗

A Clinicopathological Study of 29 Spitzoid Melanocytic Lesions With ALK Fusions, Including Novel Fusion Variants, Accompanied by Fluorescence In Situ Hybridization Analysis for Chromosomal Copy Number Changes, and Both TERT Promoter and Next-Generation Sequencing Mutation Analysis.Semantic proximity Read ↗

Spitz Spindle Cell/Reed Nevus With SQSTM1 :: NTRK2 Fusion and Atypical Features in an Older Male Patient: A Case Report and Review of LiteratureSemantic proximity Read ↗

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Spitz Tumor With SQSTM1::NTRK2 Fusion: A Clinicopathological Study of 5 CasesSemantic proximity Read ↗

Activating Structural Alterations in MAPK Genes Are Distinct Genetic Drivers in a Unique Subgroup Of Spitzoid NeoplasmsSemantic proximity Read ↗

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