Article
Whole body irradiation induces IFN-gamma production in BALB/c mice by preventing the appearance of a V alpha 14(+)NK T downregulatory population.
Cytokine - 1 Sept 2000
Dieli F, Taniguchi M, Asherson G L, Sireci G, Di Sano C, Cigna D, Salerno A
Abstract excerpt
Lymph node cells from TNCB-immune BALB/c mice fail to produce IFN-gamma when exposed to antigen in vitro. Conversely, lymph node cells of irradiated (550 rads) BALB/c mice produce IFN-gamma. Transfer experiments show that normal BALB/c mice contain cells which suppress IFN-gamma production. These downregulatory cells are CD4(+)alpha beta(+)and rearrange the invariant V alpha 14-J alpha 281 T cell receptor alpha...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.