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Article

Structure-based design of selective and potent inhibitors of protein-tyrosine phosphatase beta.

The Journal of biological chemistry - 4 Jun 2004

Lund Ida Katrine, Andersen Henrik Sune, Iversen Lars Fogh, Olsen Ole Hvilsted, Møller Karin Bach, Pedersen Anja Kallesøe, Ge Yu, Holsworth Daniel D, Newman Michael J, Axe Frank U, Møller Niels Peter Hundahl

Abstract excerpt

Protein-tyrosine phosphatases (PTPs) are considered important therapeutic targets because of their pivotal role as regulators of signal transduction and thus their implication in several human diseases such as diabetes, cancer, and autoimmunity. In particular, PTP1B has been the focus of many aca...

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PMID: 15024017
DOI: 10.1074/jbc.M313027200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15024017-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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