Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mouse tumor model for neurofibromatosis type 1.

Science (New York, N.Y.) - 10 Dec 1999

Vogel K S, Klesse L J, Velasco-Miguel S, Meyers K, Rushing E J, Parada L F

Abstract excerpt

Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder characterized by increased incidence of benign and malignant tumors of neural crest origin. Mutations that activate the protooncogene ras, such as loss of Nf1, cooperate with inactivating mutations at the p53 tumor suppressor gene during malignant transformation. One hundred percent of mice harboring null Nf1 and p53 alleles in cis synergize to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Transformation, Neoplastic
Share to Genes, Neurofibromatosis 1
Share to Genes, p53

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Loss of Heterozygosity

Share to Neural Crest

Share to Neurofibromatosis 1

Share to Sarcoma

Share to Schwann Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 10591653
DOI: 10.1126/science.286.5447.2176
PMCID: PMC3079436

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mouse tumor model for neurofibromatosis type 1.PMID 10591653Read ↗

Mouse models of tumor development in neurofibromatosis type 1.Semantic proximity Read ↗

Mouse models of neurofibromatosis 1 and 2.Semantic proximity Read ↗

Updated nomenclature for human and mouse neurofibromatosis type 1 genesSemantic proximity Read ↗

A mild mutator phenotype arises in a mouse model for malignancies associated with neurofibromatosis type 1.Semantic proximity Read ↗

Mouse models of neurofibromatosis type I: bridging the GAP.Semantic proximity Read ↗

Mouse models of neurofibromatosis.Semantic proximity Read ↗

Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects.Semantic proximity Read ↗

NF1 heterozygosity fosters de novo tumorigenesis but impairs malignant transformationSemantic proximity Read ↗

Neural and cancer stem cells in tumor suppressor mouse models of malignant astrocytoma.Semantic proximity Read ↗

Tumour predisposition in mice heterozygous for a targeted mutation in Nf1.Semantic proximity Read ↗

Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma.Semantic proximity Read ↗

Modeling RASopathies with Genetically Modified Mouse Models.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.