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Article

Loss-of-heterozygosity analysis of small-cell lung carcinomas using single-nucleotide polymorphism arrays.

Nature biotechnology - 1 Sept 2000

Lindblad-Toh K, Tanenbaum D M, Daly M J, Winchester E, Lui W O, Villapakkam A, Stanton S E, Larsson C, Hudson T J, Johnson B E, Lander E S, Meyerson M

Abstract excerpt

Human cancers arise by a combination of discrete mutations and chromosomal alterations. Loss of heterozygosity (LOH) of chromosomal regions bearing mutated tumor suppressor genes is a key event in the evolution of epithelial and mesenchymal tumors. Global patterns of LOH can be understood through allelotyping of tumors with polymorphic genetic markers. Simple sequence length polymorphisms (SSLPs, or...

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PMID: 10973224
DOI: 10.1038/79269

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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