Article
High-Risk Alphapapillomavirus Oncogenes Impair the Homologous Recombination Pathway
3 Aug 2017
Abstract excerpt
ABSTRACT Persistent high-risk genus human Alphapapillomavirus (HPV) infections cause nearly every cervical carcinoma and a subset of tumors in the oropharyngeal tract. During the decades required for HPV-associated tumorigenesis, the cellular genome becomes significantly destabilized. Our analysis of cervical tumors from four separate data sets found a significant upregulation of the homologous-recombination (HR)...
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