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Article

Selectivity of mu-opioid receptor determined by interfacial residues near third extracellular loop.

European journal of pharmacology - 1 Sept 2000

Bonner G, Meng F, Akil H

Abstract excerpt

We hypothesized that the selectivity profile of the rat mu-opioid receptor for opioid receptor-selective ligands is determined by the nature of the amino acid residues at highly divergent sites in the ligand-binding pocket. To determine which characteristics of these residues contribute to opioid receptor ligand selectivity, we made various mutant receptors that replaced the Lys(303) and Trp(318) residues near...

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Identifiers

PMID: 10969141
DOI: 10.1016/s0014-2999(00)00578-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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