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Article

Morphine-induced internalization of the L83I mutant of the rat μ-opioid receptor.

British journal of pharmacology - 1 Jan 2015

Cooke A E, Oldfield S, Krasel C, Mundell S J, Henderson G, Kelly E

Abstract excerpt

BACKGROUND AND PURPOSE: Naturally occurring single-nucleotide polymorphisms (SNPs) within GPCRs can result in alterations in various pharmacological parameters. Understanding the regulation and function of endocytic trafficking of the μ-opioid receptor (MOP receptor) is of great importance given its implication in the development of opioid tolerance. This study has compared the agonist-dependent trafficking and...

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Identifiers

PMID: 24697554
DOI: 10.1111/bph.12709
PMCID: PMC4292971

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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