Article

Spatial targeting of the prostaglandin receptor EP2 to very early endosomes co-ordinates PGE2-mediated cAMP signaling in decidualizing human endometrium

2024-03-12

Abstract excerpt

<h4>Summary</h4> Decidualization denotes the differentiation of endometrial stromal cells into specialized decidual cells, essential for embryo implantation and pregnancy. The process requires coordinated activation of both progesterone and cAMP signaling pathways, which converge on downstream transcription factors. PGE2 and relaxin, acting respectively through their Gαs-coupled GPCRs EP2 and RXFP1, are putative...

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Literature Corpus work: 64e967a6-36d0-56f6-a8d3-67c152d45dae
DOI: 10.1101/2024.03.07.582712

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