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Article

Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex.

Science (New York, N.Y.) - 1 Sept 2000

May M J, D'Acquisto F, Madge L A, Glöckner J, Pober J S, Ghosh S

Abstract excerpt

Activation of the transcription factor nuclear factor (NF)-kappaB by proinflammatory stimuli leads to increased expression of genes involved in inflammation. Activation of NF-kappaB requires the activity of an inhibitor of kappaB (IkappaB)-kinase (IKK) complex containing two kinases (IKKalpha and IKKbeta) and the regulatory protein NEMO (NF-kappaB essential modifier). An amino-terminal alpha-helical region of...

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Identifiers

PMID: 10968790
DOI: 10.1126/science.289.5484.1550

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex.PMID 10968790Read ↗

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NF-&#954;B in Human Disease: Current Inhibitors and Prospects for De Novo Structure Based Design of InhibitorsSemantic proximity Read ↗

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