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Article

Noncanonical NF-κB signaling is limited by classical NF-κB activity.

Science signaling - 4 Feb 2014

Gray Carolyn M, Remouchamps Caroline, McCorkell Kelly A, Solt Laura A, Dejardin Emmanuel, Orange Jordan S, May Michael J

Abstract excerpt

Precise regulation of nuclear factor κB (NF-κB) signaling is crucial for normal immune responses, and defective NF-κB activity underlies a range of immunodeficiencies. NF-κB is activated through two signaling cascades: the classical and noncanonical pathways. The classical pathway requires inhibitor of κB kinase β (IKKβ) and NF-κB essential modulator (NEMO), and hypomorphic mutations in the gene encoding NEMO...

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Identifiers

PMID: 24497610
DOI: 10.1126/scisignal.2004557
PMCID: PMC3960999

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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