Article
Factors with conformational effects on haemostatic serpins: implications in thrombosis.
Thrombosis and haemostasis - 1 Sept 2007
Hernández-Espinosa David, Ordóñez Adriana, Vicente Vicente, Corral Javier
Abstract excerpt
Serpins are key actors of systems involving proteolytic reactions, such as the haemostatic system, as they are irreversible suicide inhibitors of serine proteases. The structural flexibility and physical properties of serpins that are required for their efficient inhibitory mechanism also make th...
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