Article

Prevalence of Duffy null and its impact on Hydroxyurea dosing in children with sickle cell disease

2025-02-27

Abstract excerpt

Duffy null phenotype is common in people of African ancestry and is associated with lower baseline white blood cell (WBC) and neutrophil counts. We evaluated whether presence of the Duffy null phenotype had any association with neutropenia in our patients with sickle cell disease on hydroxyurea (HU). We found a statistically significant difference (p=0.006) in HU maximum tolerated dose (MTD) in patients with Duffy...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c820ad29-463f-5d16-880e-4cece970e23a
DOI: 10.22541/au.174064171.17181937/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Prevalence of Duffy null and its impact on Hydroxyurea dosing in children with sickle cell diseaseDOI 10.22541/au.174064171.17181937/v1Read

Prevalence of Duffy null and its impact on hydroxyurea in young children with sickle cell disease in the United StatesSemantic proximity Read

Characterization of the phenotypic consequences of the Duffy-null genotypeSemantic proximity Read

White blood cell ranges and frequency of neutropenia by Duffy genotype status.Semantic proximity Read

Absolute neutrophil count nadir in healthy pediatric patients with the Duffy-null phenotype.Semantic proximity Read

Role of Duffy-Negative Phenotype in Pediatric Sickle Cell Population.Semantic proximity Read

Duffy-Null Phenotype-Associated Neutropenia is the Most Common Etiology for Leukopenia/Neutropenia Referrals to a Tertiary Children's Hospital.Semantic proximity Read

Absolute neutrophil count by Duffy status among healthy Black and African American adultsSemantic proximity Read

Multinational Assessment of Absolute Neutrophil Counts and White Blood Cell Counts Among Healthy Duffy Null AdultsSemantic proximity Read

The Duffy-null genotype and risk of infection.Semantic proximity Read

Lack of Duffy antigen expression is associated with organ damage in patients with sickle cell disease.Semantic proximity Read

Neutrophil counts in persons of African origin.Semantic proximity Read

When non-Whiteness becomes a conditionSemantic proximity Read