Article
Plasmodium vivax and the Duffy antigen: a paradigm revisited.
Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine - 1 Sept 2010
Mercereau-Puijalon O, Ménard D
Abstract excerpt
The Duffy blood group antigen is the portal of entry of the Plasmodiumvivax malaria parasite into human red blood cells and the receptor for a number of CXC and CC chemokines. We review here epidemiological data and evidence derived from therapeutic or experimental human infections associating P. vivax and the Duffy glycoprotein and laboratory studies indicating that P. vivax uses the Duffy antigen as a receptor...
Topics
- Africa
- Animals
- Antimalarials
- Blood Group Antigens
- Duffy Blood-Group System
- Erythrocytes
- Gene Deletion
- Gene Expression Regulation
- Humans
- Madagascar
- Malaria, Vivax
