Article
Measurement of HPRT mutations in splenic lymphocytes and haemoglobin adducts in erythrocytes of Lewis rats exposed to ethylene oxide.
Mutation research - 17 Dec 1999
Tates A D, van Dam F J, Natarajan A T, van Teylingen C M, de Zwart F A, Zwinderman A H, van Sittert N J, Nilsen A, Nilsen O G, Zahlsen K, Magnusson A L, Törnqvist M
Abstract excerpt
Young adult male Lewis rats were exposed to ethylene oxide (EO) via single intraperitoneal (i.p.) injections (10-80 mg kg-1) or drinking water (4 weeks at concentrations of 2, 5, and 10 mM) or inhalation (50, 100 or 200 ppm for 4 weeks, 5 days week-1, 6 h day-1) to measure induction of HPRT mutations in lymphocytes from spleen by means of a cloning assay. N-ethyl-N-nitrosourea (ENU) and...
Topics
- Administration, Inhalation
- Administration, Oral
- Animals
- Carcinogens
- Chromosome Aberrations
- DNA Adducts
- Erythrocytes
- Ethylene Oxide
- Ethylnitrosourea
- Guanine