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Article

Enhanced sensitivity of multiple myeloma cells containing PTEN mutations to CCI-779.

Cancer research - 1 Sept 2002

Shi Yijiang, Gera Joseph, Hu Liping, Hsu Jung-hsin, Bookstein Robert, Li Weiqun, Lichtenstein Alan

Abstract excerpt

Recent work identifies the AKT kinase as a potential mediator of tumor expansion in multiple myeloma. The finding of PTEN mutations in several myeloma cell lines suggests that loss of PTEN function may be one mechanism by which AKT activity is increased in this disease. Because PTEN-deficient myeloma cells may have up-regulated activity of the mammalian target of rapamycin (mTOR), downstream of AKT, they may be...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12208757

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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