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Article

Activation of the PI3K-AKT pathway in human malignant mesothelioma cells

9 Feb 2009

Abstract excerpt

Malignant mesothelioma (MM) is a highly aggressive neoplasm, which is associated with asbestos exposure. The dysregulated phosphatidylinositol 3-kinase (PI3K)-AKT pathway plays an important role in cell proliferation, survival and motility in various cancers. In this study, we analyzed the activation status and underlying mechanisms of this pathway in MM cells using 21 cell lines. AKT activation was observed in...

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Identifiers

PMID: 21475810
DOI: 10.3892/mmr_00000081

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