Article
Analysis of estrogen receptor interaction with a repressor of estrogen receptor activity (REA) and the regulation of estrogen receptor transcriptional activity by REA.
The Journal of biological chemistry - 17 Nov 2000
Delage-Mourroux R, Martini P G, Choi I, Kraichely D M, Hoeksema J, Katzenellenbogen B S
Abstract excerpt
The transcriptional activity of nuclear hormone receptors is known to be modulated by coregulator proteins. We found that the repressor of estrogen receptor activity (REA), a protein recruited to the hormone-occupied estrogen receptor (ER), decreased the transcriptional activity of ER, both when ER was acting directly through DNA response elements as well as when it was tethered to other transcription factors....
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