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Article

Genetic and clinical features of hemoglobin H disease in Chinese patients.

The New England journal of medicine - 24 Aug 2000

Chen F E, Ooi C, Ha S Y, Cheung B M, Todd D, Liang R, Chan T K, Chan V

Abstract excerpt

BACKGROUND: Normally, one pair of each of the two alpha-globin genes, alpha1 and alpha2, resides on each copy of chromosome 16. In hemoglobin H disease, three of these four alpha-globin genes are affected by a deletion, a mutation, or both. We studied the alpha1-globin gene abnormalities and the clinical and hematologic features of Chinese patients with hemoglobin H disease in Hong Kong. METHODS: We assessed the...

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Identifiers

PMID: 10954762
DOI: 10.1056/NEJM200008243430804

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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