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Article

Genotype-phenotype correlation in patients with deletional and nondeletional mutations of Hb H disease in Southwest of Iran.

Scientific reports - 22 Mar 2022

Hamid Mohammad, Keikhaei Bijan, Galehdari Hamid, Saberi Alihossein, Sedaghat Alireza, Shariati Gholamreza, Mohammadi-Anaei Marziye

Abstract excerpt

We studied the alpha-globin gene genotypes, hematologic values, and transfusion-dependence of patients with Hb H disease. Molecular characterization of alpha-thalassemia was performed. We identified 120 patients with Hb H disease. Of these patients, 35 (29.16%) had deletional form of Hb H disease, and 85 (70.83%) had different form of non-deletional Hb H disease. The most frequently observed Hb H genotypes were...

Topics

Genetic Association Studies
Genotype
Humans
Iran
Mutation
alpha-Globins
alpha-Thalassemia

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 35319015
DOI: 10.1038/s41598-022-08986-4
PMCID: PMC8941133

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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