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Article

Polymorphisms in the genes encoding platelet-derived growth factor A and alpha receptor.

Journal of molecular medicine (Berlin, Germany) - 1 Jan 2000

Herrmann S M, Ricard S, Nicaud V, Brand E, Behague I, Blanc H, Ruidavets J B, Evans A, Arveiler D, Luc G, Poirier O, Cambien F

Abstract excerpt

Platelet-derived growth factors (PDGFs) may play an important role in the development of atherosclerosis acting as chemoattractants and mitogens for vascular smooth muscle cells and macrophages. Three dimeric forms of PDGF (AA, AB, BB) have different activities due to distinct binding properties mediated by two types of PDGF receptors (Ralpha, Rbeta). To investigate the possible contribution of molecular variants...

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Identifiers

PMID: 10954201
DOI: 10.1007/s001090000111

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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