Article
DNA sequence variants of the platelet-derived growth factor A-chain gene.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Oct 2001
Baron R, Silverman E S, Grasemann H, Collins T, Drazen J M
Abstract excerpt
BACKGROUND: Platelet-derived growth factor A-chain (PDGF-A) is a potent connective tissue mitogen implicated in lung growth and development. PDGF-A may have a role in asthma through effects on fibroblasts and bronchial smooth muscle cells. OBJECTIVE: To test the hypothesis that there exist variations in the PDGF-A gene associated with the asthma phenotype. METHODS: We screened genomic DNA from normal and...
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