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Article

Survival in Alzheimer's disease is shorter in women carrying heterozygosity at codon 129 of the PRNP gene and no APOE epsilon 4 allele.

Dementia and geriatric cognitive disorders - 1 Jan 2008

Giannattasio Claudia, Poleggi Anna, Puopolo Maria, Pocchiari Maurizio, Antuono Piero, Dal Forno Gloria, Wekstein David R, Matera Maria G, Seripa Davide, Acciarri Adele, Bizzarro Alessandra, Lauria Alessandra, Masullo Carlo

Abstract excerpt

We assessed the role of the APOE genotype and prion protein polymorphism at codon 129 in predicting the clinical duration of 92 neuropathologically confirmed sporadic Alzheimer's disease patients. Analyses of survival showed that the absence of the APOE epsilon 4 allele in heterozygous codon 129 PRNP carriers is a negative predictor of survival. When this subgroup of patients was stratified by sex, the effect of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18332630
DOI: 10.1159/000119730

Genes

APOE
PRNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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