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Article

Polymorphism at codon 174 of the prion-like protein gene is not associated with sporadic Alzheimer's disease.

Neuroscience letters - 8 Nov 2002

Infante Jon, Llorca Javier, Rodero Lucía, Palacio Enrique, Berciano José, Combarros Onofre

Abstract excerpt

Alzheimer's disease (AD) and prion diseases are associated with the occurrence of protein aggregates called amyloid fibrils, containing the amyloid-beta peptide in AD, and a modified form (PrP(Sc)) of the normal cellular prion protein (PrP(c)) in prion diseases. PrP(c) is encoded by the prion protein gene, and a common polymorphism at codon 129 of this gene is a determinant of susceptibility to acquired and...

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Source

Identifiers

PMID: 12399017
DOI: 10.1016/s0304-3940(02)00941-2

Genes

PRND

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Polymorphism at codon 174 of the prion-like protein gene is not associated with sporadic Alzheimer's disease.PMID 12399017Read ↗

Polymorphisms within the prion-like protein gene (Prnd) and their implications in human prion diseases, Alzheimer's disease and other neurological disorders.Semantic proximity Read ↗

Polymorphisms within the prion (PrP) and prion-like protein (Doppel) genes in AD.Semantic proximity Read ↗

First report of polymorphisms in the prion-like protein gene (PRND): implications for human prion diseases.Semantic proximity Read ↗

Examination of the human prion protein-like gene doppel for genetic susceptibility to sporadic and variant Creutzfeldt-Jakob disease.Semantic proximity Read ↗

Polymorphisms in the prion protein gene and in the doppel gene increase susceptibility for Creutzfeldt-Jakob disease.Semantic proximity Read ↗

Polymorphisms at codons 56 and 174 of the prion-like protein gene (PRND) are not associated with sporadic Creutzfeldt-Jakob disease.Semantic proximity Read ↗

Polymorphism at 3' UTR +28 of the prion-like protein gene is associated with sporadic Creutzfeldt-Jakob disease.Semantic proximity Read ↗

[Genetic background of human prion diseases].Semantic proximity Read ↗

Codon 129 polymorphism of prion protein gene in sporadic Alzheimer's disease.Semantic proximity Read ↗

Significant association of a M129V independent polymorphism in the 5′ UTR of the <i>PRNP</i> gene with sporadic Creutzfeldt-Jakob disease in a large German case-control studySemantic proximity Read ↗

Polymorphism at codon 129 of the prion protein gene is not associated with sporadic AD.Semantic proximity Read ↗

Is M129V of PRNP gene associated with Alzheimer's disease? A case-control study and a meta-analysis.Semantic proximity Read ↗

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