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Article

Codon 129 polymorphism of the human prion protein influences the kinetics of amyloid formation.

The Journal of general virology - 1 Aug 2006

Lewis Patrick A, Tattum M Howard, Jones Samantha, Bhelt Daljit, Batchelor Mark, Clarke Anthony R, Collinge John, Jackson Graham S

Abstract excerpt

The human prion protein (PrP) has a common polymorphism at residue 129, which can be valine or methionine. This polymorphism has a strong influence on susceptibility to prion diseases and on prion-strain properties. Previous work has shown that this amino acid variation has no measurable effect on the native structure of cellular PrP (PrPC). Here, it is shown that the polymorphism does not change the efficiency...

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Identifiers

PMID: 16847141
DOI: 10.1099/vir.0.81630-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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