Oncogenic ras induces gastrin gene expression in colon cancer.

doi:10.1016/s0016-5085(98)70085-x

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Article

Oncogenic ras induces gastrin gene expression in colon cancer.

Gastroenterology - 1 Nov 1998

Nakata H, Wang S L, Chung D C, Westwick J K, Tillotson L G

Abstract excerpt

BACKGROUND & AIMS: The expression of gastrin, as a tumor growth factor, is significantly increased in some colon cancers compared with the low levels found in normal mucosa. The aim of this study was to elucidate the transcriptional mechanisms of gastrin induction in colon cancer. METHODS: Gastri...

Topics

Calcium-Calmodulin-Dependent Protein Kinases
Colonic Neoplasms
Enzyme Inhibitors
Flavonoids
Gastrins
Gene Expression Regulation, Neoplastic
Genes, Reporter
Genes, ras
Genotype
Humans
Luciferases
Mitogen-Activated Protein Kinase Kinases
Phosphorylation
Promoter Regions, Genetic
Protein Kinase Inhibitors
RNA, Messenger

Source

Open in PubMed

Identifiers

PMID: 9797369
DOI: 10.1016/s0016-5085(98)70085-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9797369-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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