Article
Oncogenic ras induces gastrin gene expression in colon cancer.
Gastroenterology - 1 Nov 1998
Nakata H, Wang S L, Chung D C, Westwick J K, Tillotson L G
Abstract excerpt
BACKGROUND & AIMS: The expression of gastrin, as a tumor growth factor, is significantly increased in some colon cancers compared with the low levels found in normal mucosa. The aim of this study was to elucidate the transcriptional mechanisms of gastrin induction in colon cancer. METHODS: Gastrin messenger (mRNA) levels and K-ras genotype were determined in colon cancer cell lines and surgical specimens. Colon...
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