Article
Identification of differentially expressed genes in models of melanoma progression by cDNA array analysis: SPARC, MIF and a novel cathepsin protease characterize aggressive phenotypes.
Experimental dermatology - 1 Dec 2003
Rumpler G, Becker B, Hafner C, McClelland M, Stolz W, Landthaler M, Schmitt R, Bosserhoff A, Vogt T
Abstract excerpt
Currently, the scale and consistency of changes of gene expression profiles in models of melanoma progression are largely unknown. Therefore, we investigated siblings of cell lines or malignant melanomas (MM), which have been selected by nude mouse passages for (a). increased tumorigenicity (local ECM-independent growth), (b). metastatic potential, or (c). selected for increase invasiveness using the Boyden...
Topics
- Animals
- Blotting, Northern
- Cell Cycle
- Cell Line
- Cell Line, Tumor
- DNA, Complementary
- Disease Progression
- Escherichia coli
- Gene Expression Regulation
- Humans