Article
Evaluation of recombinant transferrin-binding protein B variants from Neisseria meningitidis for their ability to induce cross-reactive and bactericidal antibodies against a genetically diverse collection of serogroup B strains.
Infection and immunity - 1 Jan 1997
Rokbi B, Mignon M, Maitre-Wilmotte G, Lissolo L, Danve B, Caugant D A, Quentin-Millet M J
Abstract excerpt
Transferrin-binding protein B (TbpB) is a surface-exposed protein, variable among strains of Neisseria meningitidis, that has been considered as a vaccine candidate. To define a TbpB molecule that would give rise to broadly cross-reactive antibodies with TbpB of many strains, specific antisera we...
Topics
- Antibodies, Bacterial
- Antibody Specificity
- Bacterial Outer Membrane Proteins
- Bacterial Vaccines
- Carrier Proteins
- Cross Reactions
- Genetic Variation
- Iron-Binding Proteins
- Neisseria meningitidis
- Recombinant Proteins
- Serotyping
- Serum Bactericidal Test
- Transferrin-Binding Protein B